Dow has developed the AFFINISOL™ line of excipients to enable solubility enhancement.
Hypromellose acetate succinate (HPMCAS) has proven effective at producing stable amorphous solid dispersions for poorly soluble APIs. We will highlight:
• Utility of commercial grades of AFFINISOL™ HPMCAS
• AFFINISOL™ HPMCAS Quality by Design sample sets in the formulation of solid dispersions
• Innovative high productivity HPMCAS polymer providing similar product performance while reducing solution viscosity allowing for increased solids loading in the feed solution.
AFFINISOL™ HPMC HME provides a broader extrusion operating window, improved melt flow and resistance to color change at elevated temperatures. The study shows:
• Processing versatility of this polymer in HME
• Polymer utility in solubility enhancement